Clinical Lab Associate III, WGS at Personalis | Powderkeg

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The [Personalis NeXT Platform]( next-platform%2F&esheet=52534858&newsitemid=20211118006333&lan=en- US&anchor=Personalis+NeXT+Platform&index=2&md5=994af974cf5c973f890d0bc5a72ef63b)® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' [Clinical Laboratory]( US&anchor=Clinical+Laboratory&index=3&md5=214191f02a8e211e8a6037256ce4a478) was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists- accredited.


Located in Menlo Park, CA, we are seeking a talented and highly motivated Clinical Laboratory Associate to join our Operations Team. Under the direction of the Laboratory Manager, the successful candidate will help grow the Whole Genome and cell free DNA (cfDNA) Operations Sequencing Services Team. You will participate in the daily activities of the laboratory in order to effectively maximize turnaround time, equipment, and material utilization within budgetary constraints while adhering to quality technical standards. Primary responsibilities will be performing and assisting in laboratory tests, processes and analyses according to the laboratory’s standard operating procedures. Candidates for this position should be highly motivated, a team player, and able to thrive in a high-throughput operations environment.

The following shifts are available 1 PM – 9:30 PM OR 6 AM – 1:30 PM AND Tues - Sat OR Sun – Thurs

**Responsibilities: **

  • DNA extraction from different sample sources in a biosafety level 2 laboratory
  • Quantify DNA sample concentration following QC protocols
  • Prepare libraries for Next Generation Sequencing (NGS) using automated and manual procedures.
  • Quantify libraries using qPCR in automated and manual procedures
  • Run libraries on NGS instruments
  • Real time recording of automated sample processing workflows through a laboratory information management system (LIMS)
  • Maintain robotic liquid handlers and sequencing instruments for optimal performance
  • Determine sequencing loading schemes to generate required additional data
  • Assists in data transfer and basic QC evaluation of data
  • Track sequencing runs and manage data results through LIMS
  • Perform troubleshooting and system evaluations when necessary, in communication with the automation support team, laboratory supervisor, and/or third party technical support teams
  • Escalates issues to a supervisor when problems arise with sample processing
  • Maintain appropriate supplies and equipment to maximize department efficiency and meet established budgetary and quality goals
  • Support and ensure compliance with the laboratory’s quality control procedures and policies
  • Document all corrective actions taken when test systems deviate from the laboratory’s established performance specifications
  • Demonstrate knowledge of laboratory safety protocols
  • Demonstrate commitment to quality and continuous improvement
  • Use effective two-way communication and participate in general laboratory meetings
  • Performs other duties as assigned, including performing workflows outside of WGS and cfDNA

**Requirements: **

  • BA/BS in a biological discipline with 5 years experience or, MS in a biological discipline
  • Trains other operators on laboratory procedures
  • Works autonomously and solves complex problems within NGS laboratory processes
  • Familiarity with Hamilton, or other robotic liquid handlers desired
  • Familiarity with next-gen sequencing protocols and/ or operation of Illumina instruments desired
  • Familiarity with LIMS or sample management tracking systems desired
  • Familiarity with Quality control of samples and quantification devices (e.g., TapeStation, Qubit, qPCR)
  • Flexible and adaptive in a frequently changing environment
  • Strong communication skills - able to clearly and timely communicate problems, protocols, and results both in writing and verbally - and ability to keep complete and detailed records
  • Strong organizational skills and attention to detail
  • Ability to work as part of a team in a highly collaborative environment
  • Desire to learn new skills and grow his/her knowledge of next generation sequencing technologies
  • Strong desire to work in a demanding, high-energy, hands-on environment
  • Knowledge of Genomics is preferable

_Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package. _


Job Summary
  • Job Title
    Clinical Lab Associate III, WGS
  • Company
  • Location
    Menlo Park, CA
  • Employment Type
    Full time
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