Top BioTech Companies | Powderkeg

Top BioTech Companies

Before we hop into how biotechnology is shifting the way Americans work and live, let’s first define the oft-confused topic. Biotechnology is using biology and other sciences to make products that improve lives. Modern fields of science underneath the biotech umbrella include genomics, biomedical engineering and advanced immunology, a study largely in the limelight during the COVID-19 pandemic.

Biotechnology’s role in society has mostly been focused in research universities and hospitals. But, new regulations have made it easier for independent labs and corporations, in addition to accredited institutions, to research and innovate inside the biotech industry. These new changes have allowed for untapped innovation and talent to create new value and growth.

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Top BioTech Companies
Best Companies in BioTech

Best Companies in BioTech

The companies listed below were named winners in the 2022 Powderkeg Unvalley Awards. Awards data was validated by CLA, a top 10 accounting firm and Powderkeg National Corporate Member.
3Oe Scientific
3Oe promotes human health by advancing the practical use of aqueous ozone, a powerful natural disinfectant.
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410 Medical
Durham - 410 Medical has developed a simple, intuitive solution that allows a single healthcare provider to rapidly deliver fluid to critically ill patients, improving care, and saving lives. Their device allows fast set-up, improves resuscitation speed, minimizes provider fatigue, and frees providers to address other patient care issues simultaneously. This solution is particularly useful in pre-hospital settings and the emergency department and where speed is critical and resources may be limited. It was founded in 2013 and headquartered in Durham, North Carolina.
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Adaptive Phage Therapeutics
Gaithersburg - Adaptive Phage Therapeutics provides therapeutic services intended to treat multi-drug resistant pathogenic bacteria. Its services are provided using clinical and therapeutic technology that matches phages to patient-specific bacterial infections, enabling medical researchers to develop drugs that can detect and eliminate multi-drug resistant bacteria.
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Aeglea BioTherapeutics
Austin - Aeglea BioTherapeutics is a clinical-stage biotechnology company redefining the potential of human enzyme therapeutics to benefit people with rare and devastating metabolic diseases with limited treatment options. Aeglea's lead product candidate, pegzilarginase, is in a pivotal Phase 3 trial for the treatment of Arginase 1 Deficiency and has received both Rare Pediatric Disease and Breakthrough Therapy Designation. In the second quarter of 2020, the Company initiated a Phase 1/2 clinical trial of AGLE-177 for the treatment of Homocystinuria. AGLE-177 has also been granted Rare Pediatric Disease Designation. Aeglea has an active discovery platform focused on engineering small changes in human enzymes to have big impact on the lives of patients and their families. For more information, please visit http://aeglea.com.
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Aerin Medical
Sunnyvale - Aerin Medical is a health technology company that develops therapeutic devices to improve nasal breathing. Its device utilizes low-power radiofrequency energy to remodel nasal soft tissues and address the underlying cause of nasal congestion, enabling patients suffering from nasal breathing disorders to open their nasal airway quickly, safely, and effectively.
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Aerobiotix
Miamisburg - Aerobiotix is a privately held company specializing in the development and manufacture of proprietary environmental management devices for use in institutional healthcare, home health, and commercial settings.
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Airway Therapeutics
Cincinnati - Airway Therapeutics is an early stage development company that is licensing technology from within the pulmonary research program of Cincinnati Children's Hospital Medical Center (CCHMC) for further technology platform development. This platform will enable the development of three or more products that address various market needs in the overall market for lung disorders.
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Akanocure
West Lafayette - Metastasis​ is the spread of cancer to surrounding tissues and distant organs. It is responsible for 90% of cancer deaths. Medical efforts usually fail in managing the disease once it spreads through the body. Akanocure's mission is to find therapeutic approaches that block metastatic processes. The team at Akanocure is applying the expertise of its members throughout the drug discovery and development process to create novel small molecules that will positively impact the lives of cancer patients.
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Akili Interactive Labs
Boston - Akili builds clinically validated cognitive therapeutics, assessments, and diagnostics that look and feel like video games. It aims to develop a new type of electronic medicine that can be deployed remotely directly to any patient anywhere, prescribed and tracked by physicians, with the potential to be developed at a fraction of the cost of traditional medical approaches. Akili’s cognitive engine enables three separate clinical game versions for remote data capture, with features designed for patient engagement. Its proprietary adaptive mechanics allow the software to automatically personalize to the patient’s ability level with no clinician input required. Akili is based in Boston, Massachusetts.
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Alung
Pittsburgh - ALung Technologies is a medical device manufacturing company that develops intracorporeal and extracorporeal gas exchange devices for the treatment of acute and chronic respiratory disorders. Its technology utilizes Hemolung, an extracorporeal gas exchange device that circulates blood through a small catheter; and Hattler Catheter, which is placed within the central venous bloodstream in the primary vein that returns blood to the heart and is inserted directly through the skin into the vein. The company was founded in 1997 and headquartered in Pittsburgh, Pennsylvania.
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Antios
Atlanta - Antios Therapeutics is a biopharmaceutical company devoted to developing innovative therapies for viral diseases. With an experienced and proven leadership team, the company is focused on the development of its oral drug candidate for potentially curative treatment of HBV infections. Antios Therapeutics was founded by Abel De La Rosa, Douglas Mayers, and Idean Marvasty.
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ArcherDX
Boulder - ArcherDX is advancing molecular pathology with a robust technology platform for genetic mutation detection by next-generation sequencing. By combining proprietary Anchored Multiplexed PCR (AMP™) chemistry in an easy-to-use, lyophilized format and powerful bioinformatics software, the Archer® platform dramatically enhances genetic mutation identification and discovery. ArcherDX provides oncology-focused research products and is pursuing regulatory approval for multiple companion diagnostic assays.
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Argonaut Manufacturing Services
Carlsbad - Your Contract Manufacturer for Life Sciences, Molecular Diagnostics, and Biopharmaceuticals.
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Asuragen
Austin - Asuragen is a fully integrated diagnostics company focused on molecular oncology and early detection of cancer, with an emphasis on microRNA. Asuragen's current diagnostics product portfolio consists of Signature® Genetic and Oncology Testing products, as well as industry leading controls and standards engineered using its patented Armored RNA® technology. In addition to its diagnostics products, Asuragen offers GLP testing services and an established cGMP manufacturing facility that allow it to span the spectrum of discovery, testing, production and commercialization.
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Aurora
Pittsburgh - Cognition Therapeutics, Inc. is focused on the discovery and development of small molecule therapeutics targeting the toxic proteins that cause the cognitive decline associated with Alzheimer's disease and other degenerative diseases of the human brain. Toxic proteins play a crucial role in a large class of disease targets, and there are currently no therapeutics available to prevent toxic protein accumulation or block their destructive effects. Cognition is founded on the unique combination of biological expertise around these targets, including proprietary assays that emphasize functional responses and proprietary medicinal chemistry that insures novel, high quality small-molecule drug candidates.
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Benchling
San Francisco - Benchling is the modern software platform purpose-built for life science R&D. Hundreds of thousands of scientists using cutting-edge techniques like CRISPR, CAR-T immunotherapy, and genetic engineering depend on our suite of cloud applications to design DNA, collaborate on experiments, manage research workflows, and make critical R&D decisions. Benchling is powering breakthrough research on biotherapeutics, biofuels, and biomaterials at leading life science companies and the world's most renowned academic labs. The company is focusing on life science collaboration, both private and public, through creating cloud-based software tools for digital DNA sequence editing, designing and running experiments, analyzing data, and sharing research. Benchling software includes an electronic lab notebook that allows researchers to document their experiments. It was founded in 2012 and is headquartered in San Francisco, California, United States.
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Biodesix
Boulder - It's Personal.
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Biofourmis
Boston - Biofourmis is a biotechnology company that augments personalized care and therapies using digital therapeutics. The company discovers, develops, and delivers clinically validated software-based therapeutics to enable better outcomes for patients. These solutions include advanced tools for clinicians to deliver personalized care and cost-effective solutions for payers. Biofourmis was founded in 2015 and headquartered in Boston, Massachusetts.
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Brickell Bio
San Diego - Vical's core technology grew out of a chance discovery and provided the cornerstones for two new biopharmaceutical industry sectors: DNA vaccines and non-viral gene therapy. Vical's management systematically leveraged that technology into a broad portfolio of independent and partnered product development programs. The first products for animal health are on the market. The first human products are approaching.
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Cardea Bio
San Diego - Cardea is developing a new generation of (bio)technology infrastructure based on proprietary biology-gated transistors. Cardean transistors leverage biocompatible graphene instead of silicon and replace optical signal observations with direct electrical molecular signal analysis. With Cardean transistors, the company and its Innovation Partners can generate streaming multi-omics data to measure real-time biological signals. Cardea is now manufacturing chips at scale and partners have started to significantly expand the amount, type, and quality of biological data they capture by building products that Conduct Biolog.
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Celularity
Florham Park - Celularity is a clinical stage biotechnology company leading the next evolution in cellular medicine by developing off-the-shelf placental-derived allogeneic cell therapies, including unmodified NK cells, genetically-modified NK cells, T cells engineered with a CAR (CAR T-cells), and mesenchymal-like adherent stromal cells (ASCs) targeting indications across cancer, infectious and degenerative diseases. Celularity believes that by harnessing the placenta’s unique biology and ready availability, it will be able to develop therapeutic solutions that address significant unmet global needs for effective, accessible, and affordable therapies.
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Cerapedics
Westminster - Cerapedics is an orthobiologics company focused on developing its proprietary biomimetic small peptide molecule (P-15) for commercialization in spinal applications. The company was founded in 2001 and is headquartered in Westminster, Colorado.
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Click Therapeutics
New York - Click Therapeutics develops and commercializes software as medical treatments for people with unmet medical needs. Through cognitive and neurobehavioral mechanisms, Click’s Digital Therapeutics™ enable change within individuals, and are designed to be used independently or in conjunction with biomedical treatments. The Clickometrics® adaptive data science platform continuously personalizes user experience to optimize engagement and outcomes. Following a groundbreaking clinical trial, Click’s industry-leading smoking cessation program is available nationwide through a wide variety of payers, providers, and employers. Click’s lead prescription program is entering into a multi-center, randomized, controlled, parallel-group, phase III FDA registration trial for the treatment of Major Depressive Disorder in adults.
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Clovis Oncology
Boulder - Clovis Oncology is a biopharmaceutical company focused on acquiring, developing and commercializing cancer treatments in the United States, Europe and other international markets. Their development programs are targeted at specific subsets of cancer, combining precision medicine with companion diagnostics to direct therapeutics to those patients most likely to benefit from them.
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Cognition Theraputics
Pittsburgh - Cognition Therapeutics, Inc. is focused on the discovery and development of small molecule therapeutics targeting the toxic proteins that cause the cognitive decline associated with Alzheimer's disease and other degenerative diseases of the human brain. Toxic proteins play a crucial role in a large class of disease targets, and there are currently no therapeutics available to prevent toxic protein accumulation or block their destructive effects. Cognition is founded on the unique combination of biological expertise around these targets, including proprietary assays that emphasize functional responses and proprietary medicinal chemistry that insures novel, high quality small-molecule drug candidates.
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Cryosa
Arden Hills - CryOSA is a medical device company developing novel treatments for obstructive sleep apnea.
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Delfi Diagnostics
Baltimore - Delfi Diagnostics detect cancer early, when it is most curable, using high precision non-invasive blood tests. It uses artificial intelligence and genome sequencing to detect unique patterns of DNA fragmentation in the blood of patients.
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Disc Medicine
Cambridge - Disc Medicine is led by an experienced team of scientists and industry experts, and supported by a panel of advisors with a strong track record of discovering and developing new and innovative therapies. Disc Medicine was founded by Atlas Venture and Brian MacDonald, with Novo Ventures and Access Biotechnology joining as additional investors.
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Elligo Health Research
Austin - Elligo Health Research is a healthcare company that revolutionizes the clinical research industry with a novel approach to common trial challenges including patient participation and enrollment, and physician participation. They provide physicians and their patients the opportunity to participate in clinical trials using advanced health care informatics. Improved access to physicians and patients means sponsors reach trial enrollment goals faster, and new products are accelerated to market, benefiting patients everywhere. It brings clinical research to physician practices, accelerating the development of pharmaceutical, biotechnology, and medical device products and therapies. Elligo Health Research was founded in 2016 and is headquartered in Austin, Texas.
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Emalex Biosciences
Chicago - Paragon Biosciences is a global healthcare company committed to accelerating biomedical research. It solves complex challenges by advancing science. Paragon focuses on four areas of life science innovation including artificial intelligence, gene therapy, synthetic biology and biopharmaceuticals. Its current portfolio includes Castle Creek Biosciences, Emalex Biosciences, Evozyne, Harmony Biosciences, Qlarity Imaging, Skyline Biosciences, and a consistent flow of incubating companies in development. Paragon stands at the intersection of human need, life science, and company creation. It was founded in 2010 and is headquartered in Northbrook, Illinois.
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Embark Veterinary
Boston - Learn about your pup's breed, health, traits, and more with the most accurate and comprehensive dog DNA test available.
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Emulate
Boston - Emulate is a privately held company that creates advanced in vitro models for understanding how diseases, medicines, chemicals, and foods affect human health. Our lab-ready Human Emulation System® includes three components: Zoë® Culture Module, Organ-Chips, and analytical software applications. The platform provides a window into the inner workings of human biology and disease—offering researchers a new technology designed to predict human response with greater precision and detail than conventional cell culture or animal-based experimental testing. Each of the Emulate proprietary Organ-Chip models—including the liver, intestine, and kidney—contains tiny hollow channels lined with tens of thousands of living human cells and tissues and is approximately the size of an AA battery. An Organ-Chip is a living, microengineered environment that recreates the natural physiology and mechanical forces that cells experience within the human body. Our founding team pioneered the Organs-on-Chips technology at the Wyss Institute for Biologically Inspired Engineering at Harvard University. Emulate holds the worldwide exclusive license from Harvard University to a robust and broad intellectual property portfolio for the Organs-on-Chips technology and related systems. For more information, please visit emulatebio.com.
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Exicure
Chicago - Exicure is Formerly Known as AuraSense Therapeuticsis. Exicure is developing a new class of immunomodulatory and gene silencing drugs against validated targets. Our 3-dimensional, spherical nucleic acid (SNA™) architecture unlocks the potential of nucleic acid therapeutics in multiple organs. Our lead programs address diseases from inflammatory disorders to oncology. SNA constructs overcome one of the most difficult obstacles to nucleic acid therapeutics: safe and effective delivery into cells and tissues. SNA constructs exhibit unparalleled transfection efficiency into numerous cell and tissue types including the skin without carriers or transfection agents. Moreover, SNAs can be used as potent immunotherapeutic agents for the treatment of cancer or infectious disease.
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Flatiron Health
New York - Flatiron Health is a healthcare technology and services company focused on accelerating cancer research and improving patient care. The company's platform enables cancer researchers and care providers to learn from the experience of every patient. Its database platform aggregates and transforms clinical and financial data from electronic medical records (EMRs) and billing systems that provide comprehensive support to the cancer care providers and life science companies. Currently, Flatiron partners with over 280 community cancer practices, seven major academic research centers, and over 15 of the top therapeutic oncology companies.
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FlexDex Surgical
Brighton - FlexDex is a minimally invasive surgery medical device technology that provides high dexterity. Its platform technology translates the surgeon’s hand, wrist, and arm movements from outside the patient into corresponding movements of an end-effector inside the patient’s body. The company was founded in 2010 and is headquartered in Brighton, Michigan.
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Fluence Bioengineering
Austin - Fluence specializes in LED-based horticultural systems for a wide variety of applications including vertical farming. Its customers are agricultural producers in indoor locations such as high-rise buildings. Potential applications range from salad vegetables and herbs to medicinal plants.
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Freenome
South San Francisco - Freenome is a biotech company developing accurate, accessible, and non-invasive disease screening products for proactively treating cancer and other diseases at their most manageable stages. The company is developing a simple blood test to detect early-stage cancer and make treatments more effective and provides a platform that helps design healthy conditions for an individual based on his/her cell-free genome. The company aims to reinvent disease management through systematized early detection and intervention. Charles Roberts, Gabriel Otte, Riley Ennis, and Michael Otte launched the company in 2014 in South San Francisco, California.
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Front Range Biosciences
Boulder - Front Range Biosciences brings modern agriculture to cannabis and hemp to improve reliability, efficiency, and safety for cultivators and consumers. They provide advanced agricultural science services to plant growers.
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Hazel Technologies
Chicago - Hazel Technologies develops biotechnology for reducing waste in the agricultural supply chain. Their product development is funded in part by the United States Department of Agriculture (USDA) and their product performance has been validated by 3rd party academic research institutions such as Cornell University. The company provides USDA-funded 1-MCP technology conditions the storage atmosphere to reduce respiration rate & increase resistance to ethylene. Hazel Technologies offers horticultural consulting services to growers and shippers, as well as develops new solutions to reduce food waste to improve the fresh produce supply chain. It also provides shelf-life extension technologies and services to combat the global food waste problem and improve profitability for its customers. Hazel Technologies was founded in 2015 and is headquartered in Chicago, Illinois, USA.
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Healionics
Seattle - Healionics has applied its expertise in synthetic biomaterials to develop a novel vascular graft (artificial blood vessel) that, unlike existing grafts, remains open to blood flow long-term without need for costly interventions. Its first commercial application will be as a more reliable means of vascular access for dialysis patients, with a subsequent application to treat peripheral artery disease. We have great results in multiple controlled animal studies, a large patent portfolio, established production capacity, and are ready to begin human studies later this year in preparation for market launch. Near-Term Problem / Market Opportunity: Vascular Access for Dialysis Kidney failure patients need to have their blood filtered 3 times per week via dialysis. This removes waste from the blood, which would otherwise cause them to die. However, current methods for repeatedly accessing the bloodstream for dialysis are unreliable. This problem is a huge contributor to the $50 billion per year that the U.S. spends on dialysis patients (7% of Medicare’s entire budget!). A vascular graft is often implanted under the skin (connecting an artery to a vein) to create an access site with sufficient bloodflow for dialysis -- but existing grafts tend to occlude quickly, requiring repeated expensive interventions to keep them open. Solution: STARgraft Because our vascular graft remains open to blood flow much longer than existing grafts, it can potentially satisfy a severe unmet clinical need for ready-to-use, safe, long-term dialysis access, while substantially reducing costs, illness and death rate among dialysis patients. Product Pipeline We have additional products in development, including an implantable port which will allow needle-free dialysis. Eliminating the use of needles would further reduce cost and illness among dialysis patients, and allow them to perform dialysis in the convenience of their own home. In addition, our platform STAR biomaterial can improve the performance of a wide range of implantable devices via its remarkable ability to prevent both infection and scar tissue. We currently have two corporate-funded development contracts to explore STAR material’s use in multiple other device applications.
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Hill-Rom
Chicago - Hill-Rom is an American company focused on medical technologies for the health care industry. Hill-Rom's product portfolio includes patient support systems, safe mobility and handling solutions, non-invasive therapeutic products for a variety of acute and chronic medical conditions, medical equipment rentals, surgical products, and information technology solutions.
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HistoSonics
Plymouth - HistoSonics provides the Edison Platform, which uses advanced imaging and proprietary sensing technology to deliver non-invasive, personalized treatments with precision and control, and uses the science of histotripsy and focused sound energy to generate pressures to liquify and completely destroy targeted tissues at sub-cellular levels.
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iCAD
Nashua - iCAD, Inc. (iCAD) is a provider of image analysis and workflow solutions that enable radiologists and other healthcare professionals to serve patients by identifying pathologies and pinpointing cancer earlier. iCAD offers a range of high-performance, expandable Computer-Aided Detection (CAD) systems and workflow solutions for mammography (film-based, digital radiography (DR) and computed radiography (CR), Magnetic Resonance Imaging (MRI), and Computed Tomography (CT)). iCAD's solutions aid in the early detection of the prevalent cancers including breast, prostate and colon cancer. The Company's CAD systems include algorithm and other technology together with standard computer and display equipment. CAD systems for the film-based analog mammography market also include a radiographic film digitizer, either manufactured by the Company or others for the digitization of film-based medical images. !
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Imagen Technologies
New York - Imagen is a healthcare company whose mission is to save patient lives by making accurate medical image interpretation universally available and affordable. Currently, over two-thirds of the world’s population doesn’t have access to basic radiology services. Through our technology and close collaboration with world-leading clinicians, we believe that we can do something about it. We take an interdisciplinary approach: we are a team of experts in machine learning, healthcare, software engineering, and regulatory affairs who research and develop assistive software for clinicians. Our FDA-cleared software analyzes the content of medical images and produces diagnoses, improving the diagnostic accuracy of clinicians by highlighting detected pathology. We are advised by some of the world’s leading scientists and medical researchers, including Turing Award winner Yann LeCun. We have raised over $100M from leading investors including Casdin, GV, DFJ, and Zach Weinberg. Imagen is based in New York and actively hiring. Are you excited about joining our mission? Reach out directly to us at recruitingteam@imagen.ai
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Inari
Boston - Inari is a biotech seed company that embraces diversity in every aspect of its business to drive innovation and help build a new food system. Our technology matches the complexity of nature using predictive design and multiplex gene editing to unlock the full potential of seed. We are always innovating, pushing the boundaries of what’s possible. Our SEEDesign platform is our point of distinction, using unsurpassed technology to enhance any crop for any geography to develop step-change products with a clear go-to-market approach.
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Inovio
Plymouth Meeting - INOVIO is a biotechnology company focused on rapidly bringing to market precisely designed DNA medicines to treat, cure, and protect people from diseases associated with HPV, cancer, and infectious diseases. INOVIO is the first and only company to have clinically demonstrated that DNA medicine can be delivered directly into cells in the body via a proprietary smart device to produce a robust and tolerable immune response. Specifically, INOVIO's lead candidate VGX-3100, currently in Phase 3 trials for precancerous cervical dysplasia, demonstrated it destroyed and cleared high-risk HPV 16 and 18 in a Phase 2b clinical trial. High-risk HPV is responsible for 70% of cervical cancer, 90% of anal cancer, and 69% of vulvar cancer.
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Inscripta
Boulder - Inscripta is developing the first benchtop platform for scalable digital genome engineering. The company’s advanced CRISPR-based platform, consisting of an instrument, consumables, software, and assays, offers a fully automated workflow that enables massively parallel, trackable editing of single cells at an unprecedented scale. Inscripta’s goal is to empower scientists whose gene editing research is stifled by current technical and licensing limitations. By providing this unique platform and engaging in collaborative business practices, such as making its MAD7™ CRISPR nuclease-free for research and development purposes, the company enables scientists to realize a new era of biological discovery. The company was founded in 2015 and is headquartered in Boulder, Colorado.
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inviCRO
Boston - inviCRO is an image science company that provides advanced data analysis services and software in the growing field of pre-clinical imaging research. In collaboration with partner imaging centers, inviCRO facilitates full-service contract research imaging services utilizing SPECT, PET, MR, CT and Optical imaging technologies. To this effort, inviCRO has developed a product line of dedicated analysis and software services addressing image processing and reporting required of a pre-clinical laboratory running imaging trials.
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Just-Evotec Biologics
Seattle - Just Evotec Biologics was founded in 2014 and acquired by Evotec in 2019. The company has an intense focus on the design of innovative and integrated technologies to accelerate the development of biotherapeutics and reduce their manufacturing cost. Core strengths include antibody discovery, molecular design, process and product design and manufacturing plant design.
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Kallyope
New York - Kallyope, we believe that the gut is the gateway to our internal world. Containing millions of neurons, the gut informs our brains about our well-being, metabolism, and nutritional state. The gut-brain axis—the communication highway between our gut and our brain—offers an unprecedented opportunity to access and influence brain centers involved in fundamental human processes. An understanding of the biology mediated by the gut and gut-brain circuits will change the way we think about food, nutrition, and human physiology
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Kaycha Group
Fort Lauderdale - WORLD'S LARGEST CANNABIS DATABASE OF LAB RESULTS, RESEARCH AND SCIENCE An eco-system for Scientific Innovation and Technology. Kaycha Group Companies: - Kaycha Labs CA, CO, FL, KY, NY, TN & OK (quality testing) - The HEMP Institute (research) - PURE lims (laboratory software) - MJ Buddy App (cannabis efficacy)
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Kaycha Labs
Davie - Kaycha Labs is a provider of cannabis and hemp testing technologies and methods. They will test your product to ensure compliance with federal and state regulations. You can count on them to fulfill all your testing needs. In addition to terpenes and pesticides, their comprehensive cannabis testing includes potency, homogeneity, heavy metals, microbial contamination, mycotoxin levels, residue solvents, and microbial contamination.
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Kernel
Culver City - Kernel is a neuroscience company that specializes in developing brain-recording technologies. Its custom-built, non-invasive brain interface acquires neural signals similar in quality to fMRI, MEG & ECoG, as easy to use as EEG. It was founded in 2016 and is headquartered in Los Angeles, California.
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Krystal Biotech
Pittsburgh - Krystal Biotech is a biopharmaceutical company using gene therapy to develop best in class treatments that provide significant clinical benefit for patients suffering from rare debilitating disorders.
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L7 Informatics
Austin - L7 Informatics provides a workflow management software platform for companies using data-intensive scientific techniques. Advances in next-generation sequencing (NGS) are enabling rapid detection and diagnosis of genetic diseases. It has developed the Enterprise Sequencing Platform (ESP) to accelerate clinical adoption of sequencing and provide a platform for clinicians to easily track, manage, and interpret patient data. It is the first software designed from the ground-up that fully integrates all the requisite components of NGS data flow management, analysis, and reporting, with auditing capability. It was founded in 2012 and is headquartered in Austin, Texas.
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Lifelines Neuro
Louisville - Inspired by our users, Lifelines Neuro Company creates products and solutions that help our customers perform at their best every day, so they can provide the highest quality care for patients. Our platform reflects our ability to anticipate our users' needs and emerging industry trends to create intuitive products that enable neurodiagnostics without boundaries. Lifelines Neuro is known for its excellence in developing and engineering the finest EEG amplifiers found anywhere. We are part of SIDIS, a global, privately held purpose-driven company that is dedicated to advancing human health. Our Rendr Platform software is a powerful cloud-computing solution for EEG acquisition and review. We imagine EEG anywhere, available 24/7/365, so physicians are connected to their patients in real-time, all the time.
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LifeNome
New York - LifeNome is a B2B2C Precision Health AI company headquartered in New York City. LifeNome leverages biological, physiological, and behavioral data to provide science-based precision needs and risk assessments and targeted health and wellness interventions in the nutrition, health, and wellness (personal care) sectors. Team: LifeNome co-founders Raya Khanin (Weizman PhD, Royal Society Fellowship), Ali Mostashari (MIT PhD, 15 years in tech R&D), and Mario Storga (PhD, KTH, UofZ, Design Society) are each in the top 20 cited scholars in the world in their respective fields of computational genomics, complexity science, and semantic networks in the world. Team consists 30 individuals with 15 PhDs based in NYC and Europe. What we Do: We take DNA data (genotyped, exome, WGS) alongside with wearables/device data and lifestyle data to provide B2B personalized health and wellness analytics for the nutrition, fitness, preventative health (insurtech) and personal care (beauty tech) industries. Technology: We use an advanced genomics AI engine (for insiders: hierarchical clustering, network-based causal inference models, embedded biovectors similar to NLP embedding applied to genotype-phenotype networks) validated with over 530,000 genotype-phenotype individual data sets from 14 different countries. Traction: Our current partners are some of the world's most prominent brands (Zurich Insurance, Allergan, PEPSI, Unilever, Biologique Recherche, etc.) and we have secured multi-million licensing deals for the next 5 years and hope to aggressively grow our clients in 2021 and 2022. To get access to our deck, please email partnerships@lifenome.com
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LMT Surgical
Milton - LMT Surgical is a provider of innovative medical technologies and exceptional customer service throughout Australia, New Zealand and the Pacific Region. LMT Surgical continues to grow and fulfil its brand promise by following its core values of professionalism, integrity, enthusiasm, commitment and teamwork. Building solid relationships with surgeons and nurses alike, delivering quality products and having fun along the way are all part of LMT Surgical philosophy. Supporting Orthopaedic, Neurosurgical, Plastics, Biologics, MedSurg, SportsMed, Vascular and Cardio-Thoracic specialities, LMT is well known for introducing innovative products and services to the benefit of the healthcare industry and in particular the patient. LMT Surgical is proud to support the healthcare industry in a variety of ways including education and at times charitable foundations in the forms of donations of all types including products to those in need both nationally and internationally. Founded in July 2000, by Kerry Lawford and Jon Mills, LMT Surgical is proud to be an Australian owned and run Company.
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MBX Biosciences
Carmel - MBX Biosciences is a biotechnology company that develops therapies to treat rare endocrine diseases where there is inadequate treatment available. It focuses on the discovery, development, and commercialization of first-in-class endocrine therapeutics. The company was founded in 2018 and headquartered in Carmel, Indiana.
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MiRus
Marietta - MiRus is a medical device company focused on designing innovative solutions for the treatment of spinal and orthopedic degeneration and deformities.
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Molecular Templates
Austin - Molecular Templates is a biopharmaceutical company with a novel protein platform for the development of new therapeutics against cancer. The company has a lead compound for melanoma that is expected to enter into clinical trials in the next two years and is developing additional compounds against a variety of other cancers.
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Neocis
Miami - Neocis develops robot-assisted dental implant surgery with the aim of transforming dental surgery using advanced robotics. The company is the developer and manufacturer of Yomi, a robotic device for dental surgery commercially available in the USA and was cleared by the U.S. Food and Drug Administration. The company created Yomi aiming to focus on enhancing dental surgeons’ capabilities and advancing patient care through the latest technology. Neocis operates with dental surgeons to understand the needs with the focus on overcoming surgical and treatment challenges. Neocis was founded in 2009 and is headquartered in Miami, Florida.
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Neuralink
San Francisco - Neuralink develops a brain-machine interface that provides solutions for those with paralysis. Neuralink engages in the development of high-bandwidth brain-machine interfaces. It is driven to building devices that will help people with paralysis and inventing new technologies that will expand abilities, community, and, world.
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NovaSignal
Los Angeles - NovaSignal is a medical technology company commercializing a robotic cerebral ultrasound system. Robotic System combines non-invasive ultrasound, robotics, and artificial intelligence to assess real-time cerebral blood flow.
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Noveome Biotherapeutics
Pittsburgh - Noveome Biotherapeutics is a clinical-stage company focusing on breakthrough therapies for the regenerative repair of inflamed or damaged tissues.
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NuProbe
Houston - We accelerate technology innovation in precision diagnostics to enable diseases to be detected, treated and cured earlier for better outcomes with lower costs.
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Onkos Surgical
Parsippany-Troy Hills - Onkos Surgical is a privately-held surgical oncology company that brings new technology and solutions to surgical oncologists. There are huge opportunities for innovation where the complexity of the disease state requires more diverse solutions. Onkos Surgical will be 100% focused on bringing new technology and solutions to surgical oncologists who serve a population of which a large portion of the patients are children and the broader population may require personalized solutions.
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On Target Laboratories
West Lafayette - On Target Laboratories, LLC engages in discovering, developing, and commercializing small molecules that target specific pathological cells, when conjugated with fluorescent dyes. It offers folate and other targeting agents that target, lung, uterine, kidney, breast, colon, pancreatic, and prostate cancer cells. The company was incorporated in 2010 and is based in Northbrook, Illinois.
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OpenTrons
OpenTrons is a developer of a pipetting robot technology designed to automate experiments. The company's technology is automated laboratory equipment that automates experiments by using Python language, enabling scientific researchers to make the process faster and less tiresome.
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Opentrons Labworks
OpenTrons is a developer of a pipetting robot technology designed to automate experiments. The company's technology is automated laboratory equipment that automates experiments by using Python language, enabling scientific researchers to make the process faster and less tiresome.
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OriGen Biomedical
Austin - We create medical products which improve people’s lives.
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OrthoPediatrics
Warsaw - OthoPediatrics is a bioscience company dedicated to improving the resources available for treating children's orthopedic conditions through inventing, designing, and distributing innovative and anatomically appropriate implants, unique instrumentation and biologics for pediatric and small stature patients. The QCR by OrthoPediatrics is a game changing, disruptive technology. With an operating sound level just above a whisper and no vibration, the OrthoPediatrics QCR completely removes anxiety due to the noise and vibration. The self advancing technology of the crunching" blade in the QCR cuts through up to eight layers of casting material at a rate of approximately 1/2 inch per second with little to no debris.
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Paige
New York - Paige was founded in 2017 by Thomas Fuchs, Dr.Sc., and colleagues from Memorial Sloan Kettering Cancer Center. The Company builds computational pathology products designed so patients and their care teams can make effective, more informed treatment decisions. With this new class of diagnostic devices positioned to drive the future of pathology, Paige created a platform to deliver this novel technology to pathologists to transform their workflow and increase diagnostic confidence and productivity. Paige’s lightweight platform was purpose-built with pathologists to offer an intuitive user experience, minimize IT burden and costs while ensuring patient safety and data privacy. Paige’s products deliver insights to pathologists so they can arrive efficiently at more precise diagnoses for patients. Paige is the first company to receive FDA breakthrough designation for computational pathology products.
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PathAI
Boston - PathAI’s services solve challenging pathology problems faced by the research and pharmaceutical industry. The PathAI platform provides end-to-end automation for reliable, scalable, and cost-effective long-term solutions. PathAI is developing technology that assists pathologists in making rapid and accurate diagnoses for every patient, every time. The company was founded in 2016 and based in Boston, Massachusetts.
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Pattern Bioscience
Austin - 700,000 people die from bacterial infections worldwide every year, and the CDC and WHO have declared the threat of drug resistance presents one of the greatest public health challenges of our time. Pattern is building a dream team of scientists and visionaries dedicated to addressing this global problem with faster, smarter diagnostics for more precise treatment. You'll work alongside managers who know the ropes at the FDA and have already developed multiple diagnostics platforms. They also make a mean chimichurri. If you're ready to make a contribution to the world and have fun doing it, this is the place for you.
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Pear Therapeutics
Boston - Pear Therapeutics is a provider of a software-based digital therapeutics platform designed to treat disease and enhance the efficacy of pharmaceuticals. The company's platform combines novel digital interventions with drugs to enhance efficacy well beyond anything that is commercially available or in clinical development, enabling clients to get better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective services for payors.
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PharmaJet
Golden - PharmaJet is a user-friendly, inexpensive device for fluid injection into the body without a needle. Able to compete with traditional needle-syringe delivery, which inherently poses costly needle-stick, re-use, and pass-along disease risk, the technology creates a positive ROI back for every injection. Unique in the field of jet injection because of its ability to reach all target tissues (IM, SC--0.5 mL, and ID--0.1 mL) accurately and comfortably, supported by wide regulatory claims (global and country-specific) PharmaJet's platforms are the only commercially available devices that effectively address the 3 B annual immunization market. It was founded in 2005 and headquartered in Golden, Colorado.
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RayzeBio
San Diego - RayzeBio is focused on improving outcomes for people with cancer by harnessing the power of targeted radioisotopes. As the emerging leader in radiopharmaceuticals, RayzeBio is developing an innovative robust pipeline against validated oncology drug targets to deliver radioisotopes that emit alpha particles such as Actinium-225.
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Recombinetics
Eagan - Recombinetics is a developer of gene editing technologies to improve human health through advanced disease models and regenerative medicine. Its gene-editing technologies manipulate deoxyribonucleic acid (DNA) samples to add and activate genes to solve problems and also offer gene repair and gene editing tools that enable biomedical research, livestock productivity, animal agriculture, and livestock vertical markets to modify animal genomes accurately and efficiently.
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rMark bio
Chicago - rMark Bio's patented intelligence platform, Fabric, unites the real-time business objectives of a pharmaceutical company with the current activities of academic and clinical researchers to deliver next best decisions that remove inefficiencies and increase the ROI in thought leader engagements.
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Roche
Basel - Roche is a pharmaceutical and diagnostics company that focused on improving people’s lives. Roche is the owner of F. Hoffmann-La Roche Ltd. Roche is a provider of in-vitro diagnostics and drugs for cancer and transplantation. It specializes in medicines for oncology, virology, inflammation, metabolism, CNS, clinical chemistry, immunology, urinalysis, blood screening, genetics, infectious diseases, and microbiology. F. Hoffmann-La Roche Ltd. serves hospitals, research labs, private medical labs, practicing physicians, and patients. Its products include cancer treatments, such as Avastin, Herceptin, and MabThera that are also effective in the treatment of rheumatoid arthritis, anemia, and osteoporosis. F. Hoffmann-La Roche Ltd. also conducts research and development as well as production-related to molecular diagnostic reagents, test systems, and test kits. In addition, it provides automated instruments, software, consumables, and IT solutions used in in-vitro diagnostics and research.
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SafeGuard Cyber
Chicago - Hazel Technologies develops biotechnology for reducing waste in the agricultural supply chain. Their product development is funded in part by the United States Department of Agriculture (USDA) and their product performance has been validated by 3rd party academic research institutions such as Cornell University. The company provides USDA-funded 1-MCP technology conditions the storage atmosphere to reduce respiration rate & increase resistance to ethylene. Hazel Technologies offers horticultural consulting services to growers and shippers, as well as develops new solutions to reduce food waste to improve the fresh produce supply chain. It also provides shelf-life extension technologies and services to combat the global food waste problem and improve profitability for its customers. Hazel Technologies was founded in 2015 and is headquartered in Chicago, Illinois, USA.
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Saranas
Houston - Saranas is a medical device that detects internal bleeding during catheterization procedures. Its mission is to provide products that minimize complications associated with medical procedures in the interventional or surgical setting. It was founded in 2011 and headquartered in Houston, Texas.
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Scioto Biosciences
Indianapolis - Scioto Biosciences is a developer of Activated Bacterial Therapeutics (ABT) platform intended to deliver live bacteria to the gut. The company is developing innovative therapies devoted to having a transformative impact on the delivery of microbiome therapeutics, enabling medical practitioners to advance healing through microbiome therapeutics.
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Scipher Medicine
Waltham - At Scipher Medicine, we are committed to transforming the way providers prescribe drugs, as well as the way manufacturers, develop new drugs. We have built a molecular map of all protein interactions that identifies genomic signatures and links those to disease and predictive treatment outcomes. Using a simple blood sample to analyze RNA, we can predict if a patient is likely to respond to a targeted therapy before therapy is prescribed. This insight allows patients to start the most effective therapy from day one. For our first commercial product, we have developed PrismRA®, a first-of-its-kind blood test that can predict which patients with rheumatoid arthritis are less likely to respond to TNFi therapies such as Humira® and Enbrel® so that such patients can go on alternative approved drugs. We also used a different one for the ACO Payer Summit, I’ve provided that as well: Scipher Medicine is building the future of patient treatment. Most patients who are prescribed blockbuster therapies today don't respond to treatment, costing the healthcare industry billions in wasted drugs while patients continue to suffer. Scipher's platform identifies which drug will work based on the patient's fundamental disease biology, and not based on symptoms, disease classification, or medical bias. A routine blood test predicts which drug he/she will respond to, with our first product focusing on rheumatoid arthritis, ensuring that the most optimal treatment is prescribed from day one. The molecular data generated by our tests is then used to fuel novel target discovery to address a clear unmet medical need in patients who do not respond to any existing therapy.
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Seven Bridges
Boston - Seven Bridges is the industry-leading unified bioinformatics solutions company accelerating precision medicine by enabling the understanding of biomedical data. Our platform, analytic tools, and services expertise are driving discovery and drug development at the world's leading academic, biotechnology, government, hospitals, and pharmaceutical entities. Through our collaboration with the largest genomics projects, we connect the world's biomedical information to enable the most efficient analysis at scale.
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Shattuck
Austin - Shattuck is a clinical-stage biotechnology company advancing its proprietary Agonist Redirected Checkpoint (ARC) platform, a novel class of dual-function fusion proteins with applications in oncology and autoimmune disease. The company’s lead program, SL-279252 (PD1-Fc-OX40L), is being studied in a Phase I trial in collaboration with Takeda Pharmaceuticals. Its technology focuses on immuno-oncology research targeted towards patients with many cancer types, including melanoma, lung, and bladder, by endowing one molecule with multiple functions, with applicability across the entire spectrum of human disease that enables medical researchers to find a quick and painless detection of malignancy for later-stage cancer patients.
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Shoulder Innovations
Holland - Shoulder Innovations is a medical device company that has developed inset glenoid fixation technology, creating the most robust and stable glenoid platform in the industry. The company's Total Shoulder Replacement System addresses the most significant issue in shoulder arthroplasty: unreliable fixation of the glenoid implant. It also leverages this technology to create simple surgical instrumentation, which reduces operative time and cost. Shoulder Innovations designs and commercializes innovative products that demonstrate the potential for improved patient care and reduced overall cost to the healthcare system. Published results show Shoulder Innovations’ solution provides greater post-surgical implant stability, addressing the leading cause of revision surgery.
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SpectraWAVE
Bedford - Spectrawave is a medical device company that develops optical diagnostic and therapeutic devices. It enhances the diagnosis and treatment of cardiovascular diseases and primarily operates in the diagnostic equipment, medical business/industry. The Waltham, Massachusetts based company was founded in 2017.
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Strata Oncology
Ann Arbor - Strata Oncology is a precision oncology company dedicated to transforming cancer care by expanding patient access to precision medicine clinical trials and accelerating drug approval. Strata's national precision oncology platform serves the needs of patients, providers and drug developers by providing a link from patient screening to streamlined enrollment in mutation-matched clinical trials. Follow us on Twitter @StrataOncology.
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Surgical Theater
Los Angeles - Enabling Surgeons to Pre-Live the Future! Patented 3-D imaging technology allows surgeons to rehearse and refine risky surgeries in advance of the operation.
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Tempus
Chicago - Tempus is a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare. With one of the world’s largest libraries of clinical and molecular data, and an operating system to make that data accessible and useful, Tempus enables physicians to make real-time, data-driven decisions to deliver personalized patient care and in parallel facilitates discovery, development and delivery of optimal therapeutics. The goal is for each patient to benefit from the treatment of others who came before by providing physicians with tools that learn as the company gathers more data.
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Thrive Earlier Detection
Cambridge - Thrive is a healthcare company focused on saving lives by making earlier detection of cancer a routine part of medical care. It develops CancerSEEK, a liquid biopsy test that is designed to detect many cancers at earlier stages of the disease. CancerSEEK will serve as the core of Thrive’s integrated cancer information offering. The company was launched in 2019 by Third Rock Ventures, with funding from additional investors Section 32, Casdin Capital, Biomatics Capital, BlueCross BlueShield Venture Partners, The Invus Group, Camden Partners Nexus, Cowin Venture, Exact Sciences, and Gamma3.
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TissueTech
Miami - TissueTech is an innovative technology company that uses products derived from human amniotic and umbilical cord tissues. Its medical technology platform markets innovative amniotic and umbilical cord-based products, thereby enabling physicians to avail of enhanced regenerative healing technology in eye care, wound care, and orthopedics. Tissuetech was founded in 2001 and is headquartered in Miami, Florida.
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TMRW Life Sciences
New York - TMRW is a life sciences technology company setting new standards for transparency, safety, and accountability in IVF and cell management. TMRW's platform, the world's first automated cryo-management for eggs and embryos, provides a complete digital chain of custody fully integrated with a robotic storage and monitoring solution. This is in contrast to the manual and analog methods that have gone unchanged throughout the history of IVF. With TMRW's platform, clinics significantly reduce the chances of potentially devastating errors. The TMRW team includes celebrated innovators in fertility, embryology, cryo-management, automation, software development, and robotics. TMRW is founded by Joshua Abram, Alan Murray, and Dr. Jeffrey Port in 2018 and is based in New York, New York.
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Trailhead Biosystems
Cleveland - Biology. Controlled.
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Triumvira Immunologics
Austin - Triumvira Immunologics, Inc. (“Triumvira”) is an immunotherapy company co-founded in 2015 by Dr. Jonathan Bramson at McMaster University and Bloom Burton & Co., with the vision of developing novel T cell therapies that are safer and more efficacious than current cancer treatments, including chimeric antigen receptor (CAR) and engineered T cell receptor (TCR) therapies. Their proprietary T cell Antigen Coupler (TAC) technology recruits the entire natural T cell receptor and is independent of the major histocompatibility complex (MHC), allowing for the development of better therapies for a broader range of patients with solid or liquid malignancies and also with diseases other than cancer.
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TScan Therapeutics
Waltham - TScan is a biopharmaceutical company focused on the development of T-cell receptor (TCR) engineered T cell therapies (TCR-T) for the treatment of patients with cancer. The company’s lead liquid tumor TCR-T therapy candidates, TSC-100 and TSC-101, are in development for the treatment of patients with hematologic malignancies to eliminate residual leukemia and prevent relapse after hematopoietic stem cell transplantation. The company is also developing multiplexed TCR-T therapy candidates for the treatment of various solid tumors.
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Verve Therapeutics
Cambridge - Verve Therapeutics is a genetic medicines company pioneering a new approach to the care of cardiovascular disease, transforming treatment from chronic management to single-course gene editing medicines. The company’s initial two programs target PCSK9 and ANGPTL3, genes that have been extensively validated as targets for lowering blood lipids such as low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. Verve’s lead product candidate, VERVE-101, is designed to turn off the PCSK9 gene in the liver in order to disrupt blood PCSK9 protein production and thereby reduce blood LDL-C levels, with the goal of reducing a patient’s risk for cardiovascular disease. VERVE-101, currently in IND-enabling studies, is being developed initially for the treatment of patients with heterozygous familial hypercholesterolemia, a potentially fatal genetic heart disease.
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Vestaron
Durham - Vestaron produces insecticides for agriculture, animal health, non-crop, and commercial pest control applications. Vestaron Corporation develops and produces insecticides by employing peptides sourced from spiders in the United States. Its products are used in agriculture, animal health, and specialty non-crop applications, as well as in-household insects and commercial pest control applications. Vestaron Corporation was formerly known as Venomix, Inc. and changed its name to Vestaron Corporation in August 2009. The company was founded in 2005 and is headquartered in Kalamazoo, Michigan.
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Biotech Advances in the 21st Century

Marked by an increase in globalization and biotech companies’ stock, the private and public biotech industries continue to grow at a rapid pace. The United States east and west coasts have become hotbeds for medical innovation. With its access to a high-tech laborforce graduating from prestigious schools like Harvard, Boston College and Massachusetts Institute of Technology (MIT), Boston is leading the country and quite possible the world in biological transformation.

But, not far behind is the Unvalley and cities that don’t often get the spotlight that the Bay Area and Boston do for their biotechnological advancements.

As more growth is achieved, the largest biotech companies in the world together with small biotech companies in your neighborhood will continue to shape our society going forward.

And of course, top pharmaceutical companies – like Eli Lilly, Pfizer and others – also fit in with the world’s best biotech companies. During COVID-19, they rose to the occasion with extraordinary progress on vaccination in an unprecedented amount of time.

Jobs at Best BioTech Companies

Check out these opportunities at the top BioTech companies in the nation
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Biotech in the Unvalley

The list of the world’s top biotech companies continues to change everyday with each new innovation and discovery. But, what doesn’t change is their contribution to the human race and society. The top 100 biotech companies are speckled across the United States, predominantly in talent hotspots like the Bay Area and Boston, as mentioned above. The top companies include Amgen, Gilead Sciences and Celgene.

However, the Unvalley has made significant progress on attracting and retaining talent, specifically in the biotech industry and related fields. Namely, Chicago is a magnet for biotechnology and pharmaceutical innovation in recent years. With such prestigious schools like Northwestern and University of Chicago graduating science experts, the Windy City is poised for even more growth into the future.

BioTech Companies That are Hiring

Check out these BioTech Startups that are currently hiring.
Airway Therapeutics
Cincinnati - Airway Therapeutics is an early stage development company that is licensing technology from within the pulmonary research program of Cincinnati Children's Hospital Medical Center (CCHMC) for further technology platform development. This platform will enable the development of three or more products that address various market needs in the overall market for lung disorders.
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Alung
Pittsburgh - ALung Technologies is a medical device manufacturing company that develops intracorporeal and extracorporeal gas exchange devices for the treatment of acute and chronic respiratory disorders. Its technology utilizes Hemolung, an extracorporeal gas exchange device that circulates blood through a small catheter; and Hattler Catheter, which is placed within the central venous bloodstream in the primary vein that returns blood to the heart and is inserted directly through the skin into the vein. The company was founded in 1997 and headquartered in Pittsburgh, Pennsylvania.
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Aurora
Pittsburgh - Cognition Therapeutics, Inc. is focused on the discovery and development of small molecule therapeutics targeting the toxic proteins that cause the cognitive decline associated with Alzheimer's disease and other degenerative diseases of the human brain. Toxic proteins play a crucial role in a large class of disease targets, and there are currently no therapeutics available to prevent toxic protein accumulation or block their destructive effects. Cognition is founded on the unique combination of biological expertise around these targets, including proprietary assays that emphasize functional responses and proprietary medicinal chemistry that insures novel, high quality small-molecule drug candidates.
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Inovio
Plymouth Meeting - INOVIO is a biotechnology company focused on rapidly bringing to market precisely designed DNA medicines to treat, cure, and protect people from diseases associated with HPV, cancer, and infectious diseases. INOVIO is the first and only company to have clinically demonstrated that DNA medicine can be delivered directly into cells in the body via a proprietary smart device to produce a robust and tolerable immune response. Specifically, INOVIO's lead candidate VGX-3100, currently in Phase 3 trials for precancerous cervical dysplasia, demonstrated it destroyed and cleared high-risk HPV 16 and 18 in a Phase 2b clinical trial. High-risk HPV is responsible for 70% of cervical cancer, 90% of anal cancer, and 69% of vulvar cancer.
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Cognition Theraputics
Pittsburgh - Cognition Therapeutics, Inc. is focused on the discovery and development of small molecule therapeutics targeting the toxic proteins that cause the cognitive decline associated with Alzheimer's disease and other degenerative diseases of the human brain. Toxic proteins play a crucial role in a large class of disease targets, and there are currently no therapeutics available to prevent toxic protein accumulation or block their destructive effects. Cognition is founded on the unique combination of biological expertise around these targets, including proprietary assays that emphasize functional responses and proprietary medicinal chemistry that insures novel, high quality small-molecule drug candidates.
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Shoulder Innovations
Holland - Shoulder Innovations is a medical device company that has developed inset glenoid fixation technology, creating the most robust and stable glenoid platform in the industry. The company's Total Shoulder Replacement System addresses the most significant issue in shoulder arthroplasty: unreliable fixation of the glenoid implant. It also leverages this technology to create simple surgical instrumentation, which reduces operative time and cost. Shoulder Innovations designs and commercializes innovative products that demonstrate the potential for improved patient care and reduced overall cost to the healthcare system. Published results show Shoulder Innovations’ solution provides greater post-surgical implant stability, addressing the leading cause of revision surgery.
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Recombinetics
Eagan - Recombinetics is a developer of gene editing technologies to improve human health through advanced disease models and regenerative medicine. Its gene-editing technologies manipulate deoxyribonucleic acid (DNA) samples to add and activate genes to solve problems and also offer gene repair and gene editing tools that enable biomedical research, livestock productivity, animal agriculture, and livestock vertical markets to modify animal genomes accurately and efficiently.
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Unvalley Biotech Companies

Biotech has taken off in the Unvalley.

For example, Vanqua Bio is determined to solve neurodegeneration and Parkinson’s disease in the elder population. A relatively new startup to the biotech space, Vanqua raised $85 million in their Series B financing before launching their product to the public in the Summer of 2021. Want to work for a budding startup? There are plenty more where that came from.

In addition to Vanqua Bio, Abbvie is a leading biotechnology corporation based in Chicago. Abbvie is a biopharmaceutical company, combining the field of biology and pharmaceuticals. It’s a spinoff of another large corporation headquartered in Chicago, Abbott Laboratories.

Abbott is a multinational pharmaceutical company worth almost $40 billion. The makers of Pedialyte and similar health products, Abbott Labs was founded in Chicago over 140 years ago and has established itself as not only one of the American leaders in biotechnology but a global giant.

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Biotech in Indianapolis

If you’re looking for a job or company in a smaller metropolitan area, Indianapolis may be your best choice. The Circle City, aka Indianapolis, is home to two well-known biotech and pharmaceutical companies in Roche and Eli Lilly.

Founded in 1896 in Basel, Switzerland, Roche is a multinational research-based healthcare company and the largest pharmaceutical company in the world with a presence in all different regions of the world. Roche is the leading distributor of cancer treatments across the globe. In the United States Roche has a large office of folks in Indianapolis, Indiana.

Eli Lilly, on the other hand, primarily deals in pharmaceuticals. They make and distribute life-saving drugs like out of their downtown Indianapolis global headquarters. Eli Lilly is also known for its community initiatives via the Lilly Endowment, a $10 billion fund devoted to economic growth and development of the city’s citizens, arts, education and religious programs. Interested in an employer that supports social responsibility?

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Biotech Boom in North Carolina

A metropolis in the Unvalley that dominates conversation in the biotechnology and pharmaceuticals industry is Raleigh-Durham, North Carolina. Another beneficiary of a strong reputation for education and intelligence, the Research Triangle surrounding Raleigh-Durham is home to Duke University, University of North Carolina and North Carolina State University, three very high-achieving colleges that churn out successful scientists and biotechnicians. Raleigh-Durham residents Brii BioSciences and Indigo Ag each raised more than $250 million in 2018 while Precision BioSciences raised a $110 million Series B round, contributing to a wave of innovation and talent hiring over the next few years.

Whether Chicago, Indianapolis or Raleigh-Durham catches your eye, you can’t go wrong in the Unvalley. No matter your desires in an employer, the AI-powered Powderkeg talent matching service can find your dream job at a biotech company in your preferred area.

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