Clinical Lab Associate I, NGS Enrichments at Personalis | Powderkeg

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The [Personalis NeXT Platform]( next-platform%2F&esheet=52534858&newsitemid=20211118006333&lan=en- US&anchor=Personalis+NeXT+Platform&index=2&md5=994af974cf5c973f890d0bc5a72ef63b)® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' [Clinical Laboratory]( US&anchor=Clinical+Laboratory&index=3&md5=214191f02a8e211e8a6037256ce4a478) was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists- accredited.


As a team member of our small and growing biotech company, you’ll be integral to our shared mission of enabling precision medicine for cancer treatment. In support of our Clinical Lab Ops, your primary responsibilities will be performing next generation sequencing, related QC, data analysis and other tasks in support of the next generation sequencing services.


  • Primary responsibilities will be performing and assisting in laboratory tests, processes and analyses according to the laboratory’s standard operating procedures
  • Perform hybrid capture preps on NGS libraries; quality control by various quantitative methods; sample management and data transfer to sequencing team
  • Operate next generation sequencing equipment; determine sequencing loading schemes to generate required data deliverable; track sequencing runs and manage data results for customer samples
  • Perform troubleshooting, solve problems and escalate issues to a supervisor when problems arise with sample processing
  • Supports a safety and quality culture through compliance with the laboratory’s quality control procedures and policies as well as lab safety protocols
  • Document all corrective actions taken when test systems deviate from the laboratory’s established performance specifications, provide input for continuous improvement initiatives
  • Performs other duties as assigned

Basic Qualifications:

  • BA/BS in a biological discipline
  • 0-2 years of relevant laboratory experience including hands-on experience with common molecular biology techniques and principles such as nucleic acid hybridization assays, PCR, DNA/RNA isolation, enzymatic manipulation of DNA/RNA, etc.
  • Hands-on experience with Quality control of samples and quantification devices (e.g., TapeStation, Qubit, qPCR) nice to have
  • Familiarity with Hamilton or other robotic liquid handlers nice to have
  • Able to clearly and timely communicate problems, protocols, and results both in writing and verbally - and ability to keep complete and detailed records
  • Thrives in a high-energy, hands-on & collaborative environment

Preferred Qualifications:

  • Knowledge of Genomics
  • Familiarity with LIMS or sample management tracking systems

_Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package. _


Job Summary
  • Job Title
    Clinical Lab Associate I, NGS Enrichments
  • Company
  • Location
    Menlo Park, CA
  • Employment Type
    Full time
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