Sr. Scientist, Assay R&D at Personalis | Powderkeg

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The [Personalis NeXT Platform]( next-platform%2F&esheet=52534858&newsitemid=20211118006333&lan=en- US&anchor=Personalis+NeXT+Platform&index=2&md5=994af974cf5c973f890d0bc5a72ef63b)® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' [Clinical Laboratory]( US&anchor=Clinical+Laboratory&index=3&md5=214191f02a8e211e8a6037256ce4a478) was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists- accredited.


The Sr. Scientist, Assay R&D will work with a world-class, dynamic team of scientists, software engineers, assay developers, product managers, and clinicians applying our cutting-edge cancer and immuno-oncology solutions to plan, execute, analyze, and interpret impactful collaborative R&D projects. You will explore new technologies to develop and validate novel products to expand Personalis’ product portfolio. Your work will contribute to a new generation of genomics-based precision medicine products in immuno-oncology and cancer clinical trials, diagnostics, and therapeutics being used by pharma, biotech, hospitals and clinicians.


  • Keep up to date with the latest developments in NGS technologies and determine which ones can be used to improve and expand Personalis’ product portfolio.
  • Evaluate novel sequencing approaches and technologies at the raw data and application level.
  • Work with bioinformatics teams to plan experiments and analysis to validate novel procedures and analytics.
  • Work cross functionally with process development and operations teams to ensure smooth adoption of technologies.
  • Identify problems in current processes and come up with troubleshooting approaches and solutions.
  • Participate in meetings and present results.
  • Use effective two-way communication to create and maintain a collaborative working environment.
  • Support and ensure compliance with all department and company policies and procedures.

Education and Experience:

  • Ph.D or MS with a minimum of 6 years of experience in molecular biology.
  • Requires a solid understanding of next generation sequencing technology and RNA/DNA manipulation.
  • Minimum of 3 years of laboratory experience in NGS focused molecular biology and hands on sequencing experiment execution.
  • Passion for exploring new technologies and thinking creatively to solve problems.
  • Excellent organization and communication skills.
  • Excellent ability to multitask and troubleshoot complex protocols.
  • Quantitative understanding of biochemical and physical chemistry processes is required.
  • Prior experience in cancer biology is strongly desired.
  • Data analysis skills with experience in Excel, JMP, R or Python.

_Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package. _


Job Summary
  • Job Title
    Sr. Scientist, Assay R&D
  • Company
  • Location
    Menlo Park, CA
  • Employment Type
    Full time
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